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In the Fourth Century A.D., independent and determined young Charis is forbidden to become a doctor because she is a woman. Disguising herself as a eunuch she flees Ephesus for Alexandria, then the center of learning. There she apprentices to a Jewish doctor but eventually becomes drawn into Church politics and is forced once again to flee. She serves as an army doctor at a Roman outpost in Thrace until, kidnapped by barbarian Visigoths, she finds her destiny to heal and also to be a woman and a wife.