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On March 29, 1516, the city council of Venice issued a decree forcing Jews to live in il geto—a closed quarter named for the copper foundry that once occupied the area. The term stuck. In this sweeping and original interpretation, Mitchell Duneier traces the idea of the ghetto from its beginnings in the sixteenth century and its revival by the Nazis to the present. As Duneier shows, we cannot understand the entanglements of race, poverty, and place in America today without recalling the history of the ghetto in Europe, as well as later efforts to understand the problems of the American city. This is the story of the scholars and activists who tried to achieve that understanding. Their efforts to wrestle with race and poverty in their times cannot be divorced from their individual biographies, which often included direct encounters with prejudice and discrimination in the academy and elsewhere. Using new and forgotten sources, Duneier introduces us to Horace Cayton and St. Clair Drake, graduate students whose conception of the South Side of Chicago established a new paradigm for thinking about Northern racism and poverty in the 1940s. We learn how the psychologist Kenneth Clark subsequently linked Harlem’s slum conditions with the persistence of black powerlessness in the civil rights era, and we follow the controversy over Daniel Patrick Moynihan’s report on the black family. We see how the sociologist William Julius Wilson redefined the debate about urban America as middle-class African Americans increasingly escaped the ghetto and the country retreated from racially specific remedies. And we trace the education reformer Geoffrey Canada’s efforts to transform the lives of inner-city children with ambitious interventions, even as other reformers sought to help families escape their neighborhoods altogether. Ghetto offers a clear-eyed assessment of the thinkers and doers who have shaped American ideas about urban poverty—and the ghetto. The result is a valuable new understanding of an age-old concept.